The Ctrl + E shortcut breaks down after using it for an improper activity

Hi @bpiwoda,

I see this is related to a bug reported in 2021. I thought this was fixed, but looks like it has not.

Workaround
It may or may not help you now, but we hope a fix is released soon. Until then there is a unexplainable workaround as I noted in the thread above :

The weirdest thing is that when you add annotation for the whole file Shift+F2 and write an annotation on the outermost sequence, the Hotkeys/Shorcuts functionality returns!