Hi @bpiwoda,
I see this is related to a bug reported in 2021. I thought this was fixed, but looks like it has not.
Workaround
It may or may not help you now, but we hope a fix is released soon. Until then there is a unexplainable workaround as I noted in the thread above :
The weirdest thing is that when you add annotation for the whole file Shift+F2 and write an annotation on the outermost sequence, the Hotkeys/Shorcuts functionality returns!