It looks like you are performing some operation on Adobe Reader but when your program runs the Adobe is not started. You should start it in the start.
You can try to use Open/Start Application.
Prankur
Check if this article it is applying to you https://uipath-survey.secure.force.com/CaseView/articles/Knowledge/Unable-to-detect-elements-on-Adobe-Acrobat-2022-version-after-it-was-upgraded?lang=en_US
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