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Yes by using Unattended Automation it can be done.

Unattended Automation

Operating without human touch, the Unattended Robots are the key to maximized cost and performance benefits for any variety of back-office activities. Deployed by Orchestrator to either physical or virtual environments, they self-trigger work and run efficiently in batch mode. Access them remotely, with scheduling, workload management, reporting, auditing and monitoring all securely centralized.

Some points for you-

  1. If you wanna run robot with locked screen Then you can do this with Unattended Robot.It can be started from Orchestrator and can run under a locked screen without human supervision.

To Know More about Attended(Front office Robot) and UnAttended(Back office Robot) go through with below links:

Regards…!!
Aksh