For learning purpose and explore the different options to update a column value have a look here:
And fo LINQ here:
this statement is replacing in all columns as it is driven by the itemArray and is similar to
(From d In DtBuild.AsEnumerable()
Let ra = d.ItemArray.Select(Function (x) x.toString.Replace("Total","")).toArray
Select rc = DtOut.Rows.Add(ra)).CopyToDataTable