Read the excel data and use the below LINQ
// Assuming 'dt' is your DataTable
dt = dt.AsEnumerable().GroupBy(Function(x) New With {
Key .MemberID = x.Field(Of String)("Member ID#"),
Key .LastName = x.Field(Of String)("Last Name")
}).Select(Function(g) g.First()).CopyToDataTable()
Or You can use Filter activity.
or you can follow below