Editing a Single Column using LINQ

in case of only a few columns are to update go for a for each
we can do it with a regex.replace(YourString, "\D", "")

In case of the column name / index is unclear we can iterate over the ItemArray and check if its needed (also can exclude columns within the same time)

Doing it consequently on all columns:

Also have a look here:
How to Update Data Column Values of a Data Table | Community Blog