(From d in YourDataTableVar.AsEnumerable
Group d by k1=d("Name").toString.Trim, k2=d("Course").toString.Trim into grp=Group
Select r=grp.First()).CopyToDataTable
For more info on LINQ also have a look here:
[HowTo] LINQ (VB.Net) Learning Catalogue - Help / Something Else - UiPath Community Forum