Give a try on another Path, not residing within the special folder c:\Users…
If this is working, then focus on an analysis if the Access Rights for working with the Download folders are causing the exception
Also have a look on the Path combine method. This lest easy construct a Path:
@msan@ppr thank you for your input. I changed to code to what you said. Regarding the testing, earlier in the project I do the same thing using an Excel Application Scope and it does work there, but using the read file it doesn’t work. Any idea how this is caused?