I am getting error as "Exception was thrown while activating UiPath.studio.plugin.workflow.workflowhandling.designerwrapper

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I think it could help to clear the temporary packages and try again.

These would be these locations:

%USERPROFILE%\.nuget
%LOCALAPPDATA%\UiPath\.cache
%LOCALAPPDATA%\NuGet
%LOCALAPPDATA%\Temp\NuGetScratch
%LOCALAPPDATA%\Temp\nuget

If that doesn’t help, I would double check the connectivity to all the required feeds.

If not, then a clean install might be in place as it could mean things got corrupted.