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Use excel process scope activity - Find/Replace Value activity to find the desired column. This Find/Replace Value activity will give you the B column cell address.
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Use this regex to get the row number from the address string we got from step 1
strRowNumber = System.Text.RegularExpressions.Regex.Matches(strCellAddress, "\d+")(0).Value
- Now Use Write Cell activity and pass this
"E"+strRowNumberin the property - Where to write and in What to write property, give your value to be written