If you need yo search for specefic data you can use loockup Data table or lookup Excel
Also, You can use filter data table to filter data that you need depending one more than one column
And you can use LINQ Like:
DT.Asenumerable.Tolist.Findindex(Function(r) r(“Column1”).Tostring.Equals(“val1”) And r(“Column2”).Tostring.Equals(“val2”) And r(“Column3”).Tostring.Equals(“val3”))
Regards