Hi @MD_Farhan1
You can use a simple Query
dt_result = dt_input.AsEnumerable().Where(Function(x) Not dt_output.AsEnumerable().Any(Function(y) y.ItemArray.SequenceEqual(x.ItemArray))).CopyToDataTable()
I have tried with same inputs you have provided and it works
Output
Do mark it as solution if it helps ![]()

