How do i update an entire column in a Datatable using LINQ operation?

The also described datatable reconstruction approach would look in your case like:

Assign Activity:
dtResult = dtOrig.Clone

Assign Activity:
dtResult =

(From d in dtOrig.AsEnumerable
Let a = d(0).toString.Trim & " Demo"
Let ra = new Object(){a,d(1)}
Select r = dtResult.Rows.Add(ra)).CopyToDataTable