@Ben_siu ,
Could you check with this Method as shown in the Image :
After reading the Excel sheet as a Datatable, use a For Each Row in Datatable Activity and inside it put the below Expression in an Assign Activity.
CurrentRow.ItemArray = CurrentRow.ItemArray.Select(Function(x)if(String.IsNullOrWhiteSpace(x.ToString),"YourString",x.ToString)).ToArray
Then use a Write Range Activity to write the updated datatable back to excel sheet.
