Does the "Send Exchange Mail Message" activity work with Exchange Online?

Yes it does work

Basically to interact with Exchange Online, you generally don’t need to specify the version explicitly
But if u want try to Specify the lowest version of the Exchange server that is used. The options displayed in this field range from the 2007 to the 2013 version. Please note that the version number indicates the lowest level of service you support. This means that if you have a 2016 exchange server, you can select the Exchange2013 option.

The version “V2015_10_05” is a specific version of the Microsoft Graph API, which is used to communicate with Microsoft 365 services, including Exchange Online

Hope this clarifies

Cheers @atomic

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