Is it safe to remove the Microsoft ODBC Driver for SQL Server and Microsoft OLE DB Driver for SQL Server from the Orchestrator server?
Yes, it should be safe to remove the Microsoft ODBC Driver for SQL Server and Microsoft OLD DB Driver for SQL Server from the Orchestrator server.
Orchestrator uses the .NET Framework to communicate with SQL Server, specifically ADO.NET. .NET Framework is C# based and therefore does not rely on ODBC (C++) or OLE DB (VB) drivers. This StackOverflow answer is a good breakdown between the three. You can find the other data providers available to the .NET Framework here as well. So if you do need to make ODBC or OLE DB connections, .NET Framework will handle it.
Of course, as with any system change we recommend testing this out in a non production environment first if you have one. Once verified, the same change can safely be made to production.