Application not responding correctly to click activity

I am trying to click on a row in an internal database within a proprietary software. This needs to run behind a locked screen so I need to enable either the SendWindowMessages or SimulateClick. When I run the bot, the selector clicks the item but the application does not respond. I know the selector is correct, are there any similar activities I can try which may work.

If I have both these properties disabled the click works correctly, but since I will run behind a locked screen I will need to enable one of them.