Its depend on which steps you need to make from RE Frame Work as for example did you need to make stand alone script to scrap data from Web application and add it to Queue then you will use RE Frame Work to start work on transaction items one by one or you need to make all script in RE Frame work if this you just will need to add scrap data and added it into (Initilization → IntiliALLApplications Workflow) then add other steps in Process Work flow - if this is not clear enough please share with us your project if available to help you 